Analysis of Dynamic Changes in Production of Novel Coronavirus Antibodies Based on Three Kits/ 基于三种试剂盒分析新型冠状病毒特异性抗体的动态变化

In order to understand the dynamic changes of virus-specific antibodies in the serum collected from coronavirus disease 19（COVID-19）patients, three different principles of SARS-CoV-2 antibody detection kits were used in this study Fifty-eight serum samples from 33 COVID-19 confirmed cases in Gansu Province, China were tested for virus-specific antibodies including IgM, IgG, and total antibodies The detection results showed that the positive rates of IgM, IgG and total antibodies gradually increased with the time of onset: within the early 3 days, the positive rate of virus-specific antibody detected by three different kits ranged 13 6%~31 8%;within the 4~7 days, the positive rate ranged 36 4%~45 5%;within the 8~14 days, the positive rate ranged 55 6%~77 8%;after 15 days, the positive rate increased to 100% In addition, three kits were used to detect serum samples collected from healthy people, and the specificity was 99%~100% The statistical analysis indicated that there was no significant difference among the results of three kits (P > 0 05) In summary, three different principles of SARS-CoV-2 antibody detection kits have good sensitivity and specificity, which could provide assistant for clinical diagnosis;in addition, the dynamic characteristics of virus-specific antibody from serum obtained through this study provide an important scientific basis for studies such as epidemiological investigation and recessive infection study