Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

Yang Li,Lihua Zou,Qiyuan Li,Benjamin Haibe-Kains,Ruiyang Tian,Yan-Yan Li,Christine Desmedt,Christos Sotiriou,Zoltan Szallasi,J. Dirk Iglehart,Andrea L. Richardson,Zhigang C. Wang

Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer

2010

Yang Li
Lihua Zou
Qiyuan Li
Benjamin Haibe-Kains
Ruiyang Tian
Yan-Yan Li
Christine Desmedt
Christos Sotiriou
Zoltan Szallasi
J. Dirk Iglehart
Andrea L. Richardson
Zhigang C. Wang

Two amplified genes from chromosome 8q22—YWHAZ and LAPTM4B—are associated with metastatic breast cancer recurrence by promoting resistance to anthracyclines. YWHAZ codes for an antiapoptotic protein and LAPTM4B encodes a previously undescribed lysosomal protein.

Keywords:

Breast cancer
YWHAZ
LAPTM4B
Immunology
Oncology
Chromosome
Gene
Gene duplication
Metastatic breast cancer
Internal medicine
Medicine
Chemotherapy
Membrane protein

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