Abstract 17193: Absence of Thoracic Aortic Disease In ACTA2R149C/+ Mice is Associated With Defective Release of Mutant Smooth Muscle α-actin From the Chaperonin Complex

Rationale: The most common mutation in ACTA2 is p.Arg149Cys, which predisposes individuals to either thoracic aortic disease or premature onset coronary artery disease but rarely both diseases. Obj...