[Effects of long-term action of direct electric field on brain slices].

An attempt of modeling of experimental paradigm of long-term transcranial direct current stimulation (ltDCS) ofa human brain by constant electric field was undertaken on rat hippocampal slices. At anodal or cathodal direction of electric field (14 min, 250 mV/mm) statistically significant changes of population spikes (pop-spikes) amplitude in the field CAl towards increase or decrease respectively occurred in reply to stimulation of Schaffer collaterals (1/30). Long-lasting aftereffects were not observed. NMDA receptors blockade by MK-801 removed field-generated effects and caused the gradual j reduction of pon-spikes throughout all time of registration. The assumption is come out that the phenomenon of reduction of pop-spikes can reflect synaptic transforming in a "silent" condition.