Primary Malignant Fibrous Histiocytoma of Bone and Soft Tissue

A review of musculoskeletal tumors in our hospitals yielded 26 lesions with features allowing classification as malignant fibrous histiocytoma (MFH) on a purely histological basis. The clinical findings in the 26 cases with follow up information are presented. The MFH is the most common soft tissue sarcoma of late adult life, and any tumors previously diagnosed as liposarcoma, fibrosarcoma, or rhabdomyosarcoma are probably examples of MFH. The tumors of bone are previously diagnosed as giant cell tumor, plemorphic sarcoma or fibrosarcoma. They occur radiologically as osteolytic lesions with or without marginal sclerosis developing in metaphysis or epiphysis of long bone. The 5-year cumulative survival for the bone and soft tissue tumor was equally 54.0 per cent.