Emerging Paradigms in Pharmaceutical Wet Granulation

Abstract Granulation transforms the shape, size, surface, and density of powders to improve their physicochemical properties and handling. Focusing primarily on pharmaceutical wet granulation, this book provides extensive and in-depth understanding of current paradigms and practices. This chapter provides broad perspectives and overviews evolving paradigms and practices in the field of pharmaceutical wet granulation including (a) processes at the interface of different technologies such as hot melt extrusion coupled with the concepts of wet granulation or dry granulation coupled with the role of water in wet granulation (e.g., moisture activated dry granulation); (b) processes that concurrently utilize heat and mass flow dynamics, such as steam granulation, melt granulation, and freeze granulation (instead of traditional methodologies that utilize only mass (liquid binder) flow); and (c) leaps of granulation technology with improvements and extensions of particular aspects, such as mode of liquid addition (e.g., foam granulation).