Resting brain activity in disorders of consciousness: A systematic review and meta-analysisAuthor Response

Editors' Note: In WriteClick this week, authors Hannawi and Stevens respond to questions and comments about their article, “Resting brain activity in disorders of consciousness: A systematic review and meta-analysis.” Drs. Shen et al. report that they were unable to reproduce the authors' analysis using the provided settings. Drs. Garbarino and Sannita inquire whether viewing disorders of consciousness as a continuum may help explain heterogeneity in clinical measures. Author Schoenen outlines additional statistical analyses performed on the data presented in “Migraine prevention with a supraorbital transcutaneous stimulator: A randomized controlled trial.” An update related to this letter was published in the December 1, 2015, issue of Neurology® . —Megan Alcauskas, MD, and Robert C. Griggs, MD We read the article by Hannawi et al.1 on resting brain activity in disorders of consciousness. Activation likelihood estimate (ALE) meta-analysis allows the investigation of shared brain activation across individual experiments by quantitatively identifying brain locations consistently associated with different tasks or at resting state.2 When the datasets are too small for the analysis, it might not find significant convergence. The developers of GingerALE have warned that this may be the case for datasets smaller than 15 …