APOLIPOPROTEIN-B AS A PREDICTOR OF ASYMMETRIC DIMETHYLARGININE IN HYPER- CHOLESTEROLEMIC PATIENTS

Background: Regarding the correlative dependence of ADMA with biomarkers of atherogenic risk in HH, reviews of the literature reveal contradictory findings. Aim: Determinate a predictor of high level of ADMA in patients with asymptomatic, marked, nevertreated hypercholesterolemia Methods: Thirthy asymptomatic patients with marked, never-treated hypercholesterolemia and total cholesterol > 7.5mmol/l and age above 16 years. Lipid profil, creatinine, apolipoprotein-A1 and apolipoproteinB were investigated using biochemical analyzer Konelab 60i, Thermo Electron Co, USA. The plasma level of asymmetric dimethylarginine (ADMA) was tested by ELISA method. Results: A statistically significant and strong correlation dependence between ADMA and age (rxy = 0.688; p<0,0001) Statistically significant correlation dependence between ADMA and other atherosclerotic biomarkers (cholesterol of lipoproteins with high density (HDL), cholesterol of lipoproteins with low density / HDL-cholesterol, apolipoprotein-B, apolipoprotein-B/A1 ) is found. Conclusion: It is concluded that ADMA is the