Determinants of Invasively Measured Aortic Pulse Pressure andits Relationship with B-type Natriuretic Peptides in StablePatients with Preserved Left Ventricular Systolic Function
2012
Wide aortic pulse pressure (PP) and levels of natriuretic
peptides were repeatedly demonstrated as predictors of
cardiovascular morbidity and mortality even in a population
without a history of heart disease. The aim of the work was to
find determinants of invasively measured aortic pulse pressure
and B-type natriuretic peptide (BNP), and a relationship of
both markers in stable patients undergoing diagnostic coronary
angiography with preserved left ventricle systolic function.
Population and methods: A total of 386 stable patients with
left ventricle ejection fraction > 50%, without acute
myocardial infarction, aortic or mitral valve disease were
enrolled. Invasive intra-aortic blood pressure was measured
using a fluid-filled catheter in the ascending aorta. Samples
of venous blood for analysis of the BNP level were drawn before
coronary angiography. Results: We found a positive correlation
between aortic systolic blood pressure (SBP) and PP (Pearson’s
correlation coefficient = 0.44, p<0.001). Positive
relationships were determined among aortic PP and gender, age,
BNP, glycaemia, high-density lipoprotein (HDL) cholesterol,
hypertension and diabetes mellitus. Negative relationships were
found among aortic PP and height, weight and ischemic heart
disease, but only gender and age were detected as independent
factors in multivariate model. Positive correlation of BNP with
age, aortic PP, Left ventricular end diastolic pressure
(LVEDP), hypertension, smoking and a negative correlation with
creatinine, total cholesterol and ischemic heart disease were
shown; only age, creatinine, cholesterol and non- smoker status
were independent predictors of BNP value in multivariate model.
Conclusion: We found independent determinants of two important
predictive markers of cardio-vascular morbidity and mortality –
BNP and PP - in group of stable patients.
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