Efficacy of Lubiprostone in Chronic Constipation: Clinical and WorkProductivity Outcomes
2014
Objective: Chronic constipation is a common health problem that significantly affects the quality of life of patients
and results in high economic burden. This clinical study was performed to assess the efficacy of lubiprostone in the
treatment of chronic constipation using a validated constipation scoring system and the work productivity and activity
impairment questionnaire.
Methods: We prospectively enrolled 35 patients who received lubiprostone. All the patients had chronic
constipation as defined by the Rome III criteria. The patients were treated orally with a 24-μg lubiprostone capsule
twice a day. Changes in the scores before and 2 weeks after the beginning of administration were recorded and
analyzed.
Results: Of the 35 patients, 28 completed the study and were included in the efficacy analysis. The total
constipation scoring system score was significantly improved from 11.3 ± 4.8 at baseline to 8.0 ± 4.0 after 2 weeks.
Although the work activity subscale did not show a significant improvement, such an improvement was statistically
significant in the case of non-work-related activities.
Conclusion: Our results demonstrate that lubiprostone is effective in improving many chronic constipationrelated
symptoms as well as the quality of life in patients with chronic constipation.
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