Small risk ratios may have strong public health impact.

EDITOR—Traversa et al studied the hepatoxicity of nimesulide and other nonsteroidal anti-inflammatory drugs (NSAIDs).1 Nimesulide may arguably have a small risk of the more severe hepatic injuries with an odds ratio of 1.9 (95% confidence interval 1.1 to 3.81). Since the drug is widely used in Italy the population attributable risk could account …