Survival rate variation with different histological subtypes of poor prognostic male anal squamous cell carcinoma: a population-based study

// Zihao Wan 1, * , Zhihao Huang 2, * , Vikash Vikash 3, * , Kelash Rai 4 , Sindhu Vikash 5 , Liaobin Chen 1 and Jingfeng Li 1 1 Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China 2 Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China 3 Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China 4 Department of Medicine, Ziauddin Hospital, Karachi, Sindh, Pakistan 5 Department of Medicine, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana, Sindh, Pakistan * These authors have contributed equally to this work Correspondence to: Zihao Wan, email: randomvan@163.com Liaobin Chen, email: liaobinchen@163.com Jingfeng Li, email: hbjfeng@163.com Keywords: anus squamous cell carcinoma, male, tumor subtype, retrospective cohort study, SEER database Received: March 26, 2017      Accepted: August 17, 2017      Published: September 16, 2017 ABSTRACT Background and objective: The prognosis of male anal squamous cell carcinoma (MASCC) and female anal squamous cell carcinoma (FASCC) is variable. The influence of tumor subtype on the survival rate and gender is poorly known. Our study is the largest population-based study and aims to outline the difference in survival between MASCC and FASCC patients. Methods: A retrospective population-based study was performed to compare the disease-specific mortalities (DSMs) between genders related to the tumor subtypes. The Surveillance, Epidemiology, and End Results (SEER) program database was employed to obtain the data from January 1988 to December 2014. Results: A total of 4,516, (3,249 males and 1,267 females), patients with anal squamous cell carcinomas (ASCC) were investigated. The 5-year DSMs were 24.18% and 18.08% for men and women, respectively. The univariate analysis of the male basaloid squamous cell carcinoma (BSCC) and cloacogenic carcinoma (CC) patients demonstrated higher DSMs (P <0.001). Moreover, in the multivariate analysis, BSCC and CC were associated with soaring DSMs in male patients (P < 0.05). Conclusions: In the cohort of BSCC and CC patients, male patients demonstrated a considerable decrease in survival rate compared to females. A more precise classification of ASCC and individualized management for MASCC are warranted.