Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Atul Kumar,Viduth K. Chaugule,Tara E.C. Condos,Kathryn R. Barber,Clare Johnson,Rachel Toth,Ramasubramanian Sundaramoorthy,Axel Knebel,Gary S. Shaw,Helen Walden

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

2017

Atul Kumar
Viduth K. Chaugule
Tara E.C. Condos
Kathryn R. Barber
Clare Johnson
Rachel Toth
Ramasubramanian Sundaramoorthy
Axel Knebel
Gary S. Shaw
Helen Walden

The human RBR E3 ligase Parkin is captured in complex with phosphoubiquitin, revealing a cryptic ubiquitin-binding site and indicating a mechanism of cooperation between RBR modules for activation.

Keywords:

Ubiquitin ligase
Ubiquitin binding
Parkin
Molecular biology
Ligase activity
DNA ligase
Biochemistry
Ubiquitins
Biology

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