NEUROIMMUNE PATTERN IN THE COMORBIDITY BETWEEN DEPRESSION AND ALCOHOL USE DISORDER

The aim of the study is to search for biomarkers of risk and prevention of the formation of alcohol dependence on the background of depression. Antibodies are evaluated for a number of neurotransmitters, the information content of which is confirmed by preliminary studies. Materials and methods. Autoantibodies to dopamine, norepinephrine, 5-hydroxytryptamine, glutamate, gamma-aminobutyric acid were determined by ELISA in 60 controls and patients with depression and alcohol use disorder (AUD). Results. The level of antibodies to all studied neurotransmitters decreases with depression, especially complicated by alcoholism. An exception is the level of antibodies to serotonin, which increases with AUD and depression combined with AUD. Conclusion. It is assumed that this type of reaction may be a biomarker of the risk of alcoholism in depression.