Clinical outcome in significant aortic stenosis with preserved systolic function according to aortic valve area and stroke volume

Abstract Introduction and objectives Current guidelines establish an aortic valve area (AVA) cut-off point of Methods A total of 140 patients with moderate-severe aortic stenosis and preserved ejection fraction were classified in three different groups according to baseline AVA. The outcomes (aortic valve intervention or all-cause mortality) were compared using Cox regression analysis. Results After follow-up of 4.1 years (SD 1.9), death and/or aortic valve replacement occurred in 47 (84.1%) patients with AVA   1 cm2. Incidence of the combined endpoint was significantly higher in patients with AVA   1cm2 (4.71, 3.43 and 2.48 events per 100 person-years respectively) (P = .003). Survival differences stemmed only from the AVA Conclusions Patients with aortic stenosis and AVA between 0.75 and 1 cm2 showed similar evolution to those with AVA > 1 cm2. However, those with AVA