Clinicopathologic factors associated with PET/CT results in early breast cancer.

e11580 Background: Increasing data support the questionable role for 18-FDG PET/CT scan in early BC assessment. We evaluated prospectively, the impact of the main clinicopathological factors of early breast cancer on (18) fluorodeoxyglucose (FDG) uptake in the breast. Methods: 60 stage 1 (n:38) and stage 2 (n:22) BC.Of these, 16 were pre-menopausal and 44 peri-menopausal.Median age was 59 yr (range, 37-83). Mean tumor size: 18.95± 9.97 mm (range, 5-40).18-FDG PET/CT took place 15 days before surgery. Results: Forty-four (72.3%) were PET/CT positive (PP) and 16 (27.7%) were PET/CT negative ( PN). Significant association between PET/CT results and clinicopathologic factors were observed for: Tumor size: 19 (32%) ≤ 10mm (T1a and T1b) (10PP and 9 PN, median SUV 1.7); 20 (33%) 10.1-20 mm (T1c) (14PP and 6 PN, median SUV 3) and 21 (35%) 20.1 -50 mm( T2) (20 PP and 1 PN;median SUV 5.6)(p= 0.009) and histologic subtype: 44 (80%) invasive ductal carcinoma (39 PP and 9 PN; median SUV 3.4), 6 (10%) invasive lobular ...