Carbon-nitrogen material loaded cobalt catalyst and method for synthesizing pimavanserin intermediate

2016 
The invention relates to a carbon-nitrogen material loaded cobalt catalyst and a method for synthesizing pimavanserin intermediate. The catalyst is prepared by the following steps: coordinating a metal cobalt compound and cyano-containing ionic liquid in an organic solvent, and impregnating to an activated carbon carrier; and calcining at a specific temperature under an inert gas to obtain a corresponding carbon-nitrogen loaded catalyst. According to the method for catalytically synthesizing pimavanserin intermediate 4-(4-fluorobenzylamino)-1-methylpiperidine by utilizing the catalyst, 4-(4-fluorobenzylamino)-1-methylpiperidine is prepared by reductively aminating 4-flunamine serving as a raw material with N-methyl-4-piperidone or 1-methyl-4-piperidylamine with hydrogen serving as a reducing agent at a certain pressure and temperature. The catalyst has the advantages of low cost, simple preparation method, good stability, high activity and high selectivity, and can be recycled for multiple times, and is suitable for industrial production.
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