[Epidemiological analysis of GJB2,SLC26A4,mtRNA,GJB3 in nonsyndromic hearing loss in Kashi in Xinjiang].

: Objective:To investigate the epidemiological analysis of the GJB2,SLC26A4,mtRNA and GJB3 gene in nonsyndromic hearing loss in Kashi in Xinjiang.Method:In this study, we analyzed the mutations of GJB2, SLC26A4, mitochondrial mtRNA and GJB3 gene mutations in 629 cases of patients with nonsyndromic hearing loss in Kashi in Xinjiang by using the gene kit. Result:The proportion of GJB2 gene mutation was 60.29%（41/68）, the SLC26A4 and mtRNA were 8.82%（6/68）and 30.88%（21/68）respectively. Conclusion:GJB2 gene, SLC26A4, mtRNA gene are common cause of nonsyndromic hearing loss in Xinjiang.