PROTHROMBIN TIME (PT) AND ACTIVATED PARTIAL THROMBOPLASTIN TIME (APTT) IN VARIOUS BLOOD GROUP PHENOTYPES

BACKGROUND: Prothrombin time (PT) is used for assessment of extrinsic and common pathway of coagulation; whereas activated partial thromboplastin time (APTT) assesses the intrinsic and common pathway. Variation in blood group phenotypes has been linked to various diseases and their predisposition. OBJECTIVE: The key objective of this study was to correlate the prothrombin time (PT) and activated partial thromboplastin time (APTT) variations among different ABO blood group types. METHODOLOGY: This study was cross-sectional, prospective carried out at Department of Pathology and Medicine, Indus Medical College Tando Muhammad Khan for period of 8 months (February 2020 to September 2020). Total of 155 healthy participants were selected in this study. Individuals having bleeding history, medication and co-morbid conditions were excluded from the study. After informed consent, 5mL of whole blood was extracted from every participant to evaluate the coagulation profile and ABO blood group phenotype. SPSS 24.0 was used for analysis of data. A p-value of