The ongoing challenge of Pulmonary Tuberculosis in Southern Tunisia: a review of a 22-year period

Abstract Background Despite the wide use of anti-tuberculosis drugs, pulmonary tuberculosis (PTB) remains one of the most important causes of mortality and morbidity, particularly in developing countries. Therefore, combining clinical and epidemiological approach would be of a great benefit.Our study aimed to describe the epidemiological and clinical specificities of PTB and its recent chronological trends. Methods We conducted a retrospective study of all PTB new cases of any age diagnosed between 1995 and 2016 in Southern Tunisia.We applied the direct method of age-standardization using the World Standard Population to compute the age standardized incidence rate (ASIR) and the age standardized mortality rate (ASMR) per 100000 inhabitants. Results We recorded 1121 new cases with PTB among 2771 new cases of tuberculosis (40.5%). The ASIR of PTB was 5.3/100000 inhabitants/year and didn’t change over the study period (rho=1/20.3;p=0.2). Patients with PTB were mainly aged between 15 and 59 years (n=861;76.8%) and came from urban areas (n=600;55%). The median duration of treatment was 7.6 months (IQR=[6-8 months]). Successful outcome was notified in 1075 cases (95.9%). Forty-one patients died yielding an ASMR of 0.18/100000 inhabitants/year. Factors statistically associated with unsuccessful outcome included age =60 years (OR=5; p=0.001) and shorter treatment duration (6.15 months vs 7.76 months; p=0.001). Conclusion In contrast to the decline in the global PTB incidence reported worldwide and in the neighboring countries, our study revealed no significant change in the PTB rates from 1995 to 2016. Therefore, tools and strategies used to manage PTB should be strengthened by a substantial effort in both basic science and epidemiology to have better incidence curves.