A Quantitative HPLC-UV Method for Determination of Serum Sorafenib and Sorafenib N-Oxide and Its Application in Hepatocarcinoma Patients

103 Received March 3, 2014; revised and accepted May 1, 2014. Published online May 28, 2014; doi: 10.1620/tjem.233.103. Correspondence: Miki Shimada, Ph.D., Department of Pharmaceutical Sciences, Tohoku University Hospital, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, Japan. e-mail: shimada@hosp.tohoku.ac.jp A Quantitative HPLC-UV Method for Determination of Serum Sorafenib and Sorafenib N-Oxide and Its Application in Hepatocarcinoma Patients