The importance of Ki-67 proliferation index in small cell lung cancer

Asin many tumors, the relationship betweenKi-67 proliferation index and treatment response in lung cancer is emphasized. In this study, we aimed to investigate the relationship between Ki-67proliferation index (Ki-67PI) and the therapeutic effects of radiotherapy in small cell lung cancer and its effect onsurvival. Materials and Methods: The files of patients with limited stage small cell lung cancer in our hospital were retrospectively reviewedAge, sex, stage, additional disease, response to treatment according to The Response Evaluation Criteria in Solid Tumors (RECIST) and survival time were recorded. Bronchoscopic or transthoracic lung biopsy specimens were taken at the time of diagnosis were stained with Ki-67 immunohistochemical stain. Response to treatment and survival of patients were compared statistically with Ki-67 values. Results: The mean age of the patients was 65.13 ± 9.92 years, the mean survival time was 343.83 ± 273.23 days and the meanKi-67 PIwas 68.70 ± 9.49.17 patients with partial response and 13 patients with complete response were evaluated. The Ki-67 PI (62,29 ± 7,52) was lower in patients with partial response than in patients with complete response (77,08 ± 2,84) (p Conclusion: Patients with high Ki-67 had a better survival effect than those with low Ki-67, and patients with complete responses had a higher Ki-67 value.