Synthesis of an Alkynyl Methylglyoxal Probe to Investigate Non-enzymatic Histone Glycation.
2020
Methylglyoxal (MGO) is a reactive dicarbonyl metabolite that modifies histones in vivo and induces changes in chromatin structure and function. Here we report the synthesis and application of a chemical probe for investigating MGO-glycation. A two-step synthesis of a Cu-click compatible alkynyl oxoaldehyde probe (AlkMGO) via sequential Dess-Martin and Riley oxidations is presented. This synthesis elevates the accessibility and utility of an important tool for tracking, enriching and studying histone glycation to aid in understanding its underlying biochemical functions.
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