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Study of Vcam-1 Gene Expression in Normal and Tumoral Tissues in Patients With Colorectal Cancer
2017
Aim: Colorectal cancer is one of the most commonly diagnosed cancers in
the world. Cell adhesion molecules play an important role in the progression of
various cancers. It has been shown that the high-level expression of some Cell
adhesion molecule could be a new diagnostic factor for several cancers. Vascular Cell Adhesion Molecule 1(VCAM1) is a
cell surface glycoprotein that is expressed in the endothelium activated by
cytokine. Generally, VCAM-1 expression level is very poor in normal adult
tissue endothelial cells. According to the above explanation, this study was
conducted to investigate the expression of VCAM-1 in tumoral tissues and
adjacent normal tissues in Iranian colorectal cancer patients to its relation
with clinic pathological Features in patients with cancer. Methods: In this study, 60 tumoral tissues and 39 adjacent normal tumor
tissues was an evaluated by using Reverse Transcription-Polymerase Chain Reaction (RT-PCR) technique. Conclusion: A significant correlation was found between
VCAM-1 expression level and the stage, lymph nodes involvement, tumor
progression factor of cancer and sex. VCAM-1 expression level not observed in stage0
tumors. No association was seen between VCAM-1 expression and other clinical
features such as age, size of the tumor, metastasis and the number of lymph
nodes. These findings suggest that VCAM-1expression level may reflected disease
progression and elevation in VCAM-1 has prognostic significance in patients
with colorectal carcinoma. Keywords: Biomarker; Colorectal Cancer; Polymerase Chain Reaction (RT-PCR); Reverse Transcription; Vascular Cell Adhesion Molecule-1
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