Research on the change of negative symptoms in PCP-induced schizophrenia rat model

Objective To study the changes of negative symptoms in PCP-induced schizophrenia rat model. Methods Thirty newborn female SD rats randomly divided into control group, PCP-week 6 group and PCP-week 10 group(n=10 in each group). Perinatal rat treated with PCP (10 mg/kg) on postnatal days 7, 9 and 11 (10 mg/kg, ip), and sucorse intalce test(SIT), forced swimming test(FST) and resident-intruder test(RIT) were used to test the emotional and negative symptoms. Results In the SIT, there was no difference between control and PCP groups (con: (28.24±0.86) ml/kg; week 6: (26.57±1.01) ml/kg; week 10: (27.98±0.99)ml/kg, F=12.35, P>0.05). In the FST, PCP model rats showed longer still time (con: (39.32±1.98)s; week 6: (52.39±1.66)s, week 10: (55.56±1.49)s, F=3.99, P<0.05). In the RIT, PCP models rats showed less explore time ((40.31±13.56)s vs (63.90±13.12)s, (43.65±12.86)s vs (65.18±15.12)s, P<0.05) and more escape time ((19.33±2.26)s vs (9.26±1.32)s, (17.79±2.99)s vs (9.38±1.36)s, P<0.05). Conclusion Perinatal PCP injection can induce the long-lasting negative-symptoms changes. Key words: Phencyclidine; Schizophrenia; Sucrose intake test; Forced swimming test; Resident-intruder test