Fabrication of nanostructured M13 bacteriophage films on titanium surfaces

Abstract 2D aligned films prepared from engineered M13 bacteriophages (phage) have potential applications in tissue-regeneration and energy devices. TBP54–M13 phage specifically binds to acid-alkali treated titanium (Ti) surface. In this study, polyvinyl pyrrolidone–treated TBP54–M13 phage films were fabricated on Ti surfaces. The resultant film exhibited uniform nanostructure and favorable stability. This film has potential applications in surface multi–functionalization and patterning of Ti implants.