Anti-cancer nanoparticulate drug delivery system using biodegradable polymers

A B ST R A C T Cancer is a hyper proliferative disorder marked by metastasis into the vital organs of the body through invasion and angiogenesis. Biodegradable nanoparticles have been used frequently as anti-cancer drug delivery vehicles due to its splendid bioavailability, better encapsulation, and control release with less toxic properties. Various nanoparticulate systems, general synthesis and encapsulation process, control release and improvement of therapeutic value of nano-encapsulated cancer drugs are covered in this review. We have highlighted the impact of biodegradable polymer such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates in the formulation of nanoparticles for encapsulation of cancer drugs. Hence in the current review a detailed studied has been done for the delivering of cancer drugs effectively using biodegradable polymers.