Correlation of coagulation parameters with prognosis of COVID-19

Background : COVID-19 demonstrates a high mortality because of rapidly progress to severe and critical cases with respiratory distress syndrome, coagulation dysfunction, multiple organ failure, etc. Therefore, early identification of the disease expansion is very important to the clinical diagnosis and treatment of COVID-19. Aims : The aim of our study was to investigate the value of some coagulation parameters -prothrombin test (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg), D-dimer (DD), factor VIII activity (FVIII), ristocetin-cofactor von Willebrand's factor activity (vWF:RCo), von Willebrand's factor antigen (vWF:Ag), antithrombin (AT) and homocysteine (HCY) -in predicting of prognosis of COVID-19. Methods : These laboratory data were collected at hospitalization in 104 patients with COVID-19. Outcomes were divided into two types: hospital discharge ( n = 81) and death ( n = 23). Statistical analysis was performed by non-parametric methods (median (Me), 95% confidence interval (95% CI) and Mann-Whitney U test, Statistica 12.0), P < 0.05 was considered statistically significant. Results : Coagulation profiles observed in both groups of patients reflect a hypercoagulability, but PT and AT were significantly lower, while DD and HCY levels -significantly higher in patients with poor prognosis, and no difference in the other parameters was observed (data shown in the table). Conclusions : The results of this study showed that hypercoagulation was present in patients with COVID-19. Severe coagulation dysfunction is more likely to occur in critically ill patients. PT, AT, DD and HCY could serve as diagnostic indicators for disease outcome.