The Different Mechanisms ofCancer Drug Resistance: A Brief Review
2017
Anticancer
drugs resistance is a complex process that arises from altering in the drug
targets. Advances in the DNA microarray, proteomics technology and the
development of targeted therapies provide the new strategies to overcome the
drug resistance. Although a design of the new chemotherapy agents is growing
quickly, effective chemotherapy agent has not been discovered against the
advanced stage of cancer (such as invasion and metastasis). The cancer cell
resistance against the anticancer agents can be due to many factors such as the
individual’s genetic differences, especially in tumoral somatic cells. Also,
the cancer drug resistance is acquired, the drug resistance can be occurred by
different mechanisms, including multi-drug resistance, cell death inhibiting
(apoptosis suppression), altering in the drug metabolism, epigenetic and drug
targets, enhancing DNA repair and gene amplification. In this review, we
outlined the mechanisms of cancer drug resistance and in following, the
treatment failures by common chemotherapy agents in the different type of
cancers.
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