A functional variant in ZNF512B is associated with susceptibility to amyotrophic lateral sclerosis in Japanese

Aritoshi Iida1, Atsushi Takahashi2, Michiaki Kubo3, Susumu Saito3, Naoya Hosono3, Yozo Ohnishi3, Kazuma Kiyotani4, Taisei Mushiroda4, Masahiro Nakajima1, Kouichi Ozaki5, Toshihiro Tanaka5, Tatsuhiko Tsunoda6, Shuichi Oshima8, Motoki Sano9, Tetsumasa Kamei10, Torao Tokuda11, Masashi Aoki12, Kazuko Hasegawa13, Koichi Mizoguchi14, Mitsuya Morita15, Yuji Takahashi16, Masahisa Katsuno17,18, Naoki Atsuta17, Hirohisa Watanabe17, Fumiaki Tanaka17, Ryuji Kaji19, Imaharu Nakano15, Naoyuki Kamatani2, Shoji Tsuji16, Gen Sobue17, Yusuke Nakamura7,20 and Shiro Ikegawa1,∗ Laboratory for Bone and Joint Diseases and Laboratory for Statistical Analysis, Center for Genomic Medicine, RIKEN, Tokyo 108-8639, Japan, Laboratory for Genotyping Development, Laboratory for Pharmacogenetics, Laboratory for Cardiovascular Diseases, Laboratory for Medical Informatics and Laboratory for International Alliance, Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan, Department of Neurosurgery, Chiba Tokushukai Hospital, Funabashi 274-8503, Japan, Department of Neurology, Chibanishi General Hospital, Matsudo 270-2251, Japan, Department of Neurology, Chigasaki Tokushukai General Hospital, Chigasaki 253-8558, Japan, Tokushukai Group, Tokyo 102-0093, Japan, Department of Neurology, Tohoku University School of Medicine, Sendai 980-8574, Japan, Department of Neurology, National Hospital Organization Sagamihara National Hospital, Sagamihara 228-8522, Japan, Department of Neurology, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka 420-8688, Japan, Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan, Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 1138655, Japan, Department of Neurology, Graduate School of Medicine and Institute for Advanced Research, Nagoya University, Nagoya 466-8550, Japan, Department of Neurology, Graduate School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan and Department of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan