Dose intensity comparison of African-American and white patients in NSABP breast treatment trials of postoperative doxorubicin and cyclophosphamide

6111 Background: It has been proposed that ethnic neutropenia in African-American (AA) breast cancer patients leads to lower chemotherapy dose intensity (DI) compared to white (W) patients and hence to increased mortality from the disease [Hershman 2003]. Thomas et al. [2005] confirmed that AA patients in NSABP breast treatment trials had lower WBC and ANC than W counterparts and found that the total amount of chemotherapy received was no different in AA and W patients. The aim of the present study was to extend previous work to determine whether postop doxorubicin (A) and cyclophosphamide (C) DIs (as opposed to total doses) were lower in AA pts enrolled in NSABP breast cancer adjuvant treatment trials. Methods: Pooled data from AA and white (W) pts enrolled in NSABP trials B-15, B-16, B-18 (postop pts only), B-22, B-23, and B-25 (N=10,678 total: 1,040 AA pts and 9,638 W pts) were analyzed. Outcome measures were 1) total A received as a % of the total dose projected on the basis of BSA divided by total da...