The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer

Aim. To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods. A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results. SMC4 mRNA level was significantly upregulated in breast cancer tissues (). Patients with high mRNA expression of SMC4 had significantly poor survival (). Subgroup analyses show that in nontriple negative breast cancer (non-TNBC) patients, the high SMC4 mRNA expression, older age (>65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (, 95% CI 1.257-8.625, ). In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate ().Conclusion. SMC4 mRNA level is a good prognostic biomarker for patients with breast cancer.