Risk perception in genetic counselling for hereditary breast/ovarian cancer

1541 Background: The estimation of the objective risk (OR) to develop a tumour is a crucial element of genetic counselling. The estimation of the subjective risk (SR) is also important because it affects the patients distress level and influences their adhesion to clinical management. This study evaluates the perception levels of the risk to be a mutation carrier and to develop a related-cancer, the association between perceived risk and medical / psychological variables and the adequacy of the perceived risk compared to the objective risk estimated by BRCApro model. Methods: Before collecting family pedigree, the patients were informed about the clinical involvement of BRCA1/BRCA2 genes mutation, and then about their eligibility to genetic testing and objective risk as estimated by BRCApro model. At this time, questionnaires for evaluation of medical-demographic characteristics, Cancer and Genetic Risk Perception (CRP, GRP) and Hospital Anxiety Depression scale were administered. Statistical analysis was...