Lymphomatoid Granulomatosis With Involvement of the Hard Palate: A Case Report

Lymphomatoid granulomatosis (LYG) is a rare angiocentric-destructive process with Epstein-Barr virus (EBV) positive B-cells and reactive T-cells. LYG is graded with grades I–II showing rare to moderate numbers of Epstein-Barr Virus (EBV) positive B-cells (usually polyclonal or oligoclonal), and grade III showing numerous large EBV positive B-cells (usually monoclonal), likely reflecting the progressive transformation of infected B-cells (1, 2). Clinically, LYG nearly always presents in the lung but commonly involves the skin, kidney, and central nervous system (3, 4), with lymph nodes rarely being enlarged. Herein, we report an unusual case of an active erosive lesion of the hard palate in a 32-year-old female patient with a history of LYG involving the lungs.