Prognostic factors in patients with locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy (RT)

6045 Background: We sought to review the experience of our center with the treatment of patients with locally advanced salivary gland cancers and identify prognostic factors of outcome. Methods: We reviewed records of patients with malignant salivary gland tumors registered within University of Pittsburgh databases from 1980–2006. Selection criteria included newly diagnosed stage III or IV disease treated with surgery followed by postoperative RT. Patients with early stage or distant metastatic disease, history of skin or other head and neck cancer, non-salivary gland pathology, history of immunosuppresion, or previous treatment were excluded. Parameters of interest included age, gender, stage, primary site, histologic type and pathologic features (grade, perineural invasion, extracapsular spread and positive margins), and treatment type. Results: Of 492 patients initially identified, 78 met the inclusion criteria. Characteristics were as follows: Male 42/female 36; median age 59 years (21–90); stage III,...