Active Versus Passive Thaw Following Percutaneous Cryoablation of Pulmonary Tumors: Effect on Incidence, Grade, and Onset of Hemoptysis.

Background: Hemoptysis is common following percutaneous image-guided cryoablation of pulmonary tumors. Objective: To evaluate the effect of a final active thaw on the incidence, grade, and onset of hemoptysis following percutaneous cryoablation of pulmonary tumors. Methods: This retrospective cohort study included 60 consecutive CT-guided cryoablation sessions targeting 95 pulmonary tumors in 47 patients from 2017 to 2020. The final thaw of a triple-freeze protocol was active (electrical, helium-free) in 27/60 sessions (45%, active group) and passive in 33/60 sessions (55%, passive group). Incidence, onset, and management of hemoptysis were recorded using prospectively collected data. Hemoptysis, pneumothorax, and hemothorax within 30 days post ablation were graded per Common Terminology Criteria for Adverse Events version 5.0 (CTCAE). Volume of immediate post-treatment changes on CT was quantified using semi-automated segmentation. Outcomes were compared between groups using generalized estimating equation models. A parsimonious multivariable model for hemoptysis incidence was developed using purposeful selection of predefined covariates followed by bootstrap resampling. Local tumor control was compared between groups using the Kaplan-Meier method and logrank testing. Results: Hemoptysis occurred following 26/60 (43%) sessions and was self-limited (Grade 1) in 22/26 (85%). The incidence of hemoptysis was lower in the active than passive group (64% vs 19%, respectively; p=.002). The odds of hemoptysis adjusted for immediate post-treatment changes were 92% lower in the active group (OR, 0.08 [95% CI, 0.02-0.37], p=.004). The odds of hemoptysis greater than Grade 1 were 79% lower in the active group (OR, 0.21 [95% CI, 0.07-0.64], p=.006). In the active group, the onset of hemoptysis was significantly delayed (OR, 0.75 [95% CI, 0.61-0.91], p=.005). Pneumothorax (p=.60), hemothorax (p=.84), and local tumor control (p=.77) did not differ between groups. Conclusion: Active thaw following the final freeze reduces the incidence and grade of hemoptysis and delays the onset of hemoptysis following percutaneous cryoablation of pulmonary tumors without adversely affecting other procedural complications and local tumor control. Clinical Impact: Active thaw following the final freeze improves the safety profile of triple-freeze cryoablation of pulmonary tumors by reducing the incidence and grade of hemoptysis and by delaying the onset of hemoptysis beyond the immediate recovery period.