Assessment of Vitamin D status in Type 1 Diabetes Mellitus in pediatric age group

Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Type-1-Diabetes Mellitus (TIDM) results from autoimmune destruction of beta cells leading to insulin deficiency. Vitamin D deficiency (VDD) may have a role in the pathogenesis and development of T1DM by regulating immune mechanism. Materials and Methods: The aim of this study is to assess and evaluate the connection between fasting blood sugar (FBS), post prandial blood sugar (PPBS), glycated hemoglobin (HbAlc) and Vitamin D levels in children with TlDM. This study included 50 healthy controls and 50 previously diagnosed TlDM cases of both sex in the age group of 6-l5 years. 25 hydroxy Vitamin D3 (25-OH Vit D3) level was estimated by Enzyme Linked Fluorescent Assay (ELFA), FBS, PPBS by GOD-POD method, HbAlc levels by Ion Exchange Resin method. Results: Results showed a decreased 25-OH Vit D3 and an increased FBS, PPBS and HbAlc levels which are highly significant (p