Multiple Emulsions Able To Be Use For Oral Administration Of Actives Pharmaceutical Ingredients: Different Phases Physico-Chemical Parameters Study

When formulating emulsions, the preliminary tests, also known as formulation tests, constitute a step which can be long and expensive because of the quantity of reagents that can be used. A rigorous methodology could thus be of great interest, that is at the aim of our study which consists of evaluating the physico-chemical parameters of different phases used to make thus multiple emulsions. In our study, physico chemical parameters such as conductivity, pH, density, viscosity, and surface tension have been studied by direct measurement using equipment and also by means of suitable mounting. The results showed that the pH and the surface tension have an important role in the prediction of the stability of emulsions, these latter must be of the same order of magnitude. For all phases conductivity does not have too much interest apart from helping to determine the type of the emulsion. STATEMENT OF SIGNIFICANCEMultiple emulsions are of great therapeutic interest especially in the administration of medicament which can be inactivated by digestive enzymes, moreover the researches of formulation not being often easy, a control of the physicochemical parameters of the different phases would be of great interest in rapid formulations and at low cost.