Ginger was equivalent to pyridoxine hydrochloride (vitamin B6) for reducing nausea and vomiting in pregnancy

Smith C, Crowther C, Willson K, et al. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstet Gynecol 2004;103:639–45. [OpenUrl][1][PubMed][2][Web of Science][3] 
 Q In pregnant women who experience nausea and vomiting, is ginger equivalent to pyridoxine hydrochloride (vitamin B6) for controlling symptoms? Clinical impact ratings FP/GP/Obstetrics ★★★★★★☆ Obstetrics ★★★★★☆☆ ### ![Graphic][4] Design: randomised controlled equivalence trial. ### ![Graphic][5] Allocation: concealed.* ### ![Graphic][6] Blinding: blinded (patients, healthcare providers, and data collectors).* ### ![Graphic][7] Follow up period: 3 weeks. ### ![Graphic][8] Setting: a hospital in Adelaide, South Australia, Australia. ### ![Graphic][9] Patients: 291 women who were 8–16 weeks pregnant (confirmed by ultrasonography). Exclusion criteria: signs of clinical dehydration, allergy to ginger or pyridoxine, or suspicion that symptoms were not related to pregnancy. ### ![Graphic][10] Intervention: women were allocated to ginger, 350 mg capsule 3 times daily (n = 146), or pyridoxine, 25 mg capsule 3 times daily (n = 145), for 3 weeks. ### ![Graphic][11] Outcomes: nausea, dry retching, and vomiting (Rhodes Index of Nausea and Vomiting … [1]: {openurl}?query=rft.jtitle%253DObstetrics%2B%2526%2BGynecology%26rft.stitle%253DObstet%2BGynecol%26rft.issn%253D0029-7844%26rft.aulast%253DSmith%26rft.auinit1%253DC.%26rft.volume%253D103%26rft.issue%253D4%26rft.spage%253D639%26rft.epage%253D645%26rft.atitle%253DA%2Brandomized%2Bcontrolled%2Btrial%2Bof%2Bginger%2Bto%2Btreat%2Bnausea%2Band%2Bvomiting%2Bin%2Bpregnancy.%26rft_id%253Dinfo%253Apmid%252F15051552%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=15051552&link_type=MED&atom=%2Febmed%2F10%2F1%2F14.atom [3]: /lookup/external-ref?access_num=000225413900006&link_type=ISI [4]: /embed/inline-graphic-1.gif [5]: /embed/inline-graphic-2.gif [6]: /embed/inline-graphic-3.gif [7]: /embed/inline-graphic-4.gif [8]: /embed/inline-graphic-5.gif [9]: /embed/inline-graphic-6.gif [10]: /embed/inline-graphic-7.gif [11]: /embed/inline-graphic-8.gif