Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis

Suma Babu,Eric A. Macklin,Katherine E. Jackson,Elizabeth Simpson,Katy Mahoney,Hong Yu,Jason Walker,Zachary Simmons,William S. David,Paul E. Barkhaus,Laura Simionescu,Mazen M. Dimachkie,Alan Pestronk,Johnny Salameh,Michael D. Weiss,Benjamin Rix Brooks,David A. Schoenfeld,Jeremy M. Shefner,Swati Aggarwal,Merit Cudkowicz,Nazem Atassi

Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis

2019

AbstractObjective: To conduct a phase-II trial using a ranking and selection paradigm where multiple treatments are compared with limited sample size and the best is chosen for a subsequent efficac...

Keywords:

Amyotrophic lateral sclerosis
Creatine
Dose
Internal medicine
Sample size determination
Tamoxifen
Oncology
Physical therapy
Medicine
Multiple treatments
design phase

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