Nutritional status in post SARS-Cov2 rehabilitation patients

Summary Background & aims After prolonged hospitalization, the assessment of nutritional status and the identification of adequate nutritional support is of paramount importance In this observational study, we aimed at assessing the presence of a malnutrition condition in SARS-Cov2 patients after the acute phase and the effects of a multidisciplinary rehabilitation program on nutritional and functional status Methods We recruited 48 patients (26 males/22 females) admitted to our Rehabilitation Unit after discharge from acute Covid Hospitals in northern Italy with negative swab for SARS-Cov2 We used the Global Leadership Initiative on Malnutrition (GLIM) criteria to identify patients with different degrees of malnutrition Patients underwent a 3 to 4-week individual multidisciplinary rehabilitation program consisting of nutritional intervention (energy intake 27to30 kcal/die/kg and protein intake 1–1 3 g/die/kg), exercise for total body conditioning and progressive aerobic exercise with cycle- and arm-ergometer (45 min, 5 days/week) At admission and discharge from our Rehabilitation Unit, body composition and phase angle (PhA) (BIA101 Akern), muscle strength (handgrip, HG) and physical performance (Timed-Up-and-Go, TUG) were assessed Results At admission in all patients the mean weight loss, as compared to the habitual weight, was −12 1 (7 6)%, mean BMI was 25 9 (7 9) kg/m2, mean Appendicular Skeletal Muscle Index (ASMI) was 6 6 (1 7) kg/m2 for males and 5 4 (1 4) kg/m2 for females, mean phase angle was 2 9 (0 9)°, mean muscle strength (HG) was 21 1 (7 8) kg for males and 16 4 (5 9) kg for females, mean TUG value was 23 7 (19 2) s Based on GLIM criteria 29 patients (60% of the total) showed a malnutrition condition 7 out of those 29 patients (24%) presented a mild/moderate grade and 22 patients (76%) a severe grade After a rehabilitation program of an average duration of 25 days (range 13–46) ASMI increased, with statistically significant differences only in females (p = 0 001) and HG improved only in males (p = 0 0014) In all of the patients, body weight did not change, CRP/albumin (p < 0 05) and TUG (p < 0 001) were reduced and PhA increased (p < 0 01) Conclusions We diagnosed a malnutrition condition in 60% of our post SARS-Cov2 patients An individualized nutritional intervention with adequate energy and protein intake combined with tailored aerobic and strengthening exercise improved nutritional and functional status