Frequency of post-treatment surveillance and survival in localized prostate cancer: AFT-30 a national study.

6503Background: The optimal frequency of post-treatment PSA surveillance is undefined, and different existing guidelines based on expert opinions recommend frequencies ranging from 1x/year to 4x/year. Whether more frequent surveillance improves survival is unknown. Methods: Using the backbone of the National Cancer Data Base (NCDB), medical records of 10,477 randomly sampled patients diagnosed with localized prostate cancer from 2005-2010 were abstracted from 1007 sites throughout the US to provide additional data for this study. 53% of the cohort received primary radiotherapy; 47% received radical prostatectomy. Primary exposure is number of post-treatment PSA tests in the first 2 years, and primary outcome is overall survival. Results: There were 4,088 low-risk, 3,241 intermediate, and 3,148 high-risk patients. Median age at diagnosis was 64 years, and median follow-up was 8 years. At last follow-up, 17% (low-risk), 33% (intermediate), and 50% (high-risk) patients had died. Median numbers (IQR) of PSA t...