CLINICAL AND HISTOPATHOLOGIC CHARACTERISTICS OF HEREDITARY BENIGN INTRAEPITHELIAL DYSKERATOSIS

A 55-year-old male with leukoderma, retired, had a main complaint of having a white spot on the tongue, unknown evolution time. The patient had no systemic history and was an ex-smoker (35 years). Clinically, he had a white plaque on the right lateral border of the tongue, asymptomatic, 5.0 × 1.5 cm in diameter, resilient, smooth surface, homogeneous, and well delimited. In addition, he had whitish plaques in the eyes. Incisional biopsy revealed oral mucosa consisting of hyperplastic stratified squamous epithelium, with areas of acanthosis, and cells of the middle and superficial layers were vacuolized with clear cytoplasm (basket weave aspect). Underlying, fibrous connective tissue with an extensive area of skeletal muscle fibers interspersed with adipose cells was noted. Due to clinical and histopathologic findings, the diagnosis was hereditary benign intraepithelial dyskeratosis. The patient reported not knowing if anyone in the family showed the same lesion. The conduct was clinical preservation and periodic controls.