Biochemical studies on the effect of Toxoplasma infection on liver and kidney functions in mice

T he present study was carried out to study the efficacy of acute toxoplasmosis on liver and kidney functions of mice and the effect of azithromycin on treatment the infection and restore the normal values levels of liver and kidney functions to its normal values. Forty albino mice were used in this work. Liver functions were evaluated by estimation of serum total protein, serum albumin, aspartate aminotarnsferase (AST) and alanine aminotarnsferase activities (ALT). Kidney functions were also evaluated by estimation of creatinine and urea levels. Serum total protein, ALT and AST activities were increased and albumin level decreased in infected non treated mice compared with control group (non infected non treated mice). It was also noticed decrease in levels of serum T. protein, ALT and AST activities in infected and treated mice with azithromycin as compared with infected non treated mice and showed proximate level in non infected treated mice with azithromycin. Albumin level showed increase in infected and treated mice with azithromycin compared with infected non treated mice while the level also of proximate level in non infected and treated with azithromycin. There was increase in level of urea of infected non treated mice as compared with control group (non infected non treated mice) while there was no noticed a significant differences between levels of creatinine in all groups of study. It was concluded that toxoplasmosis affects liver and kidney functions which were characterized by increase levels of T. protein, ALT, AST activates and urea and decrease of most parameters of infected treated mice into normal levels that indicated the treatment with azithromycin improve the immune system of the treated mice.