Synthesis, characterization and bioevaluation of partially stabilized cements for medical applications

Materials for dental applications, i.e., white mineral trioxide aggregate (WMTA) and partial stabilized cements (PSC) were obtained using the sol-gel method. The presence of ZnO or/and CaF2 additions in the starting mixture induced changes in the composition, morphology and grindability of PSCs as compared with WMTA. The presence of foreign elements (Zn or F) in the crystalline lattice of mineralogical phases, increased their grindability. Thermal analysis (TG&DTA) was used to assess the kinetics of hydration process in binding systems based on WMTA/PSCs. The presence of foreign elements in PSCs systems increases the reactivity vs. water of these materials and consequently, the compressive strength developed after 28 days of hardening at 37°C are higher as compared with WMTA. The in vitro bioevaluation results (trypan blue staining, eukaryotic cells cycle assay by flowcytometry) accounted for a high biocompatibilty of the obtained materials demonstrating their potential use for biomedical applications. Open image in new window