Decreased digital skin microvascular blood flow before and after cold stimulus using Laser Doppler imaging in juvenile systemic sclerosis

observed 27 minutes after cold stimulus in JSS patients. All JSS patients presented scleroderma pattern in nailfold capillaroscopy with fewer number of capillaries, higher number of enlarged capillaries and deletion score compared with the other two groups (p=0.009, p=0.025, p=0.001, respectively). Conclusion In JSS patients LDI showed a lower superficial blood flow in the fingertips before and after cold stimulus compared to healthy controls and patients with Raynaud’s phenomenon. Quantification of blood flow by LDI can be useful for disease follow-up and for monitoring therapeutic interventions in JSS patients.