Epigenetics, Built Environment and Atopy

RationaleAccurate estimation of gestational age (GA) using DNA methylation (DNAm) of umbilical cord blood, a novel development, provides relevant information on developmental stage. Studies of environmental exposures on GA are plentiful, but not using DNAm GA. We evaluated associations between DNAm GA, environmental correlates of the built environment and atopy.MethodsCord blood samples from 145 selected participants in the Canadian Healthy Infant Longitudinal Development study were examined, together with allergy skin prick tests at age 1 year.Exposure to greenness using satellite imagery, and individual exposure estimates to air pollution using land use regression models were assessed at home addresses throughout pregnancy.Associations of air pollution and greenness with DNAm GA residuals were tested while adjusting for maternal and neonatal characteristics. We further examined whether sensitization related to these environmental factors and DNAm GA.ResultsThe mean GA was 276 (SD: 7.9) days, and mean DN...