Discussion on Relation Between Blood Lead Level and Transient Tic Disorder in Children

Objective To explore the relation between the level of blood lead and transient tic disorder(TTD) in children. Methods Blood lead level was determined in 180 children with TTD and 160 healthy children.58 children with excessive lead in 180 children with TTD were selected to randomly divide into groups A and B,with the ratio of 1:1.Group A carried out the treatment for removing lead with a mixture of Luzhu.At the same time, group B carried out the treatment with inosine tablets and oryzanol tablets.After one month treatment,groups A and B exchanged the therapy for a month.At the end of each treatment,tic type,tic frequency,the intensity of tics,and the impact on life in the patients of each group were observed.Before and after the treatment,the clinical symptoms of the two groups were evaluated and scored using Yale overall tic severity scale(YGTSS).Moreover,the children's blood lead levels were measured in each period of the treatment. Results The average blood lead level in children with tic was 84.73ug/L.The average blood lead level in healthy children was 49.1ug/L.There was a significant difference(P0.05).The clinical symptoms of 58 tic children with excessive lead were improved in the end of each treatment period,but their blood lead levels were reduced only after the removing lead treatment with Luzhu mixture.During the process of removing lead treatment with Luzhu mixture,blood lead level was reduced,meanwhile,tic symptoms were controlled effectively. Conclusions The average blood lead level in children with TTD is higher than that of healthy children;moreover,their clinical symptoms significantly improve with the reduced blood lead levels.Therefore,there is a positive correlation between tic disorder and blood lead level in children.