W1929 Depleting Dopaminergic Neurons in Substantia Nigra by 6-Hydroxydopamine Increases Colorectal Motility in Rat

Background & Aims: Low grade gastrointestinal inflammation is a potent etiologic factor for developing irritable bowel syndrome. We have shown that Th1 and Th2 cytokines have opposing effect on intestinal muscle contraction via 5-HT signaling in the nematode infection and T cell-mediated enteropathy. In this study, we evaluated the gastrointestinal transit In Vivo and compared to the contraction study In Vitro, and investigated the effect of Th1/Th2 cytokines on smooth muscle cells (SMCs) in T cell-mediated persistent gut motor dysfunction model. In addition, we investigated the cytokine-induced intracellular signaling mechanism toward the gut motor dysfunction. Further, the improvement of hyper-contractility by a Japanese traditional medicine daikenchuto (DKT) (Kono T et al., Surgery 146:837-4