Two Cases of Rectal Cancer Resected Curatively after Chemotherapy with CapeOX plus Bmab

We report 2 cases of locally far-advanced rectosigmoid cancer that were initially unresectable, but were successfully excised after treatment with CapeOX plus Bmab chemotherapy(capecitabine, L-OHP, and bevacizumab). Case 1: A 72-year-old man who complained of severe constipation initially received sigmoid colostomy because of far-advanced rectosigmoid cancer. After 4 courses of CapeOX plus Bmab chemotherapy administration, the size of the primary tumor remarkably decreased and curative resection could be performed. There has been no signs of recurrence for 27 months. Case 2: A 73-year-old man who complained of tenesmus initially received ileostomy because of far-advanced rectosigmoid cancer that directly invaded the appendix, ileum, and urinary bladder. After he received 3 courses of CapeOX plus Bmab chemotherapy, the primary tumor was found to have shrunk remarkably. Therefore, surgery was performed and the tumor was resected curatively. From these experiences, we conclude that some patients with locally far-advanced colorectal cancer can be treated effectively with CapeOX plus Bmab chemotherapy in a neoadjuvant setting.